New research improves accuracy of molecular quantification in high throughput sequencing

Published on February 8, 2024

A team at Oxford's Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS) has developed a new approach to significantly improve the accuracy of RNA sequencing. They pinpoint the primary source of inaccurate quantification in both short and long-read RNA sequencing, and have introduced the concept of 'majority vote' error correction leading to a substantial improvement in RNA molecular counting.